iMatinib related substance D
4-[(4-methyl-4-oxido-piperazin-4-ium-1-yl)methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide
CAS: 571186-91-9
Molecular Formula: C29H31N7O2
iMatinib related substance D - Names and Identifiers
| Name | 4-[(4-methyl-4-oxido-piperazin-4-ium-1-yl)methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide |
| Synonyms | 4-oxide iMatinib Imatinib Impurity D iMatinib related substance D Imatinib (Piperidine)-N-Oxide IMatinib (Piperidine)-4-oxide Imatinib (Piperidine)-N1-Oxide Imatinib-piperidine-4-N-oxide (under development) 4-[(4-Methyl-4-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide 4-[(4-methyl-4-oxido-piperazin-4-ium-1-yl)methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide 4-[(4-Methyl-4-oxido-piperazin-4-iuM-1-yl)Methyl]-N-[4-Methyl-3-[[4-(3-pyridyl)pyriMidin-2-yl]aMino]phenyl]benzaMide |
| CAS | 571186-91-9 |
| InChI | InChI=1/C29H31N7O2/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-35-14-16-36(2,38)17-15-35/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) |
iMatinib related substance D - Physico-chemical Properties
| Molecular Formula | C29H31N7O2 |
| Molar Mass | 509.6 |
| Melting Point | 146-149°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| Appearance | Solid |
| Color | Pale Yellow to Yellow |
| pKa | 13.23±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability | Hygroscopic |
iMatinib related substance D - Risk and Safety
| HS Code | 29333990 |
iMatinib related substance D - Introduction
4-[() methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide (4-[() methyl]-N-[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl) is a benzamide of imatinib (Imatinib). The following is an introduction to the properties, uses, methods and safety information of 4-[(methyl)]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide:
1. nature: 4-[(1) methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino phenyl]benzamide is an organic compound with a chemical formula of C27H30N8O2. It is a by-product or degradation product of imatinib, usually in the form of its hydrochloride salt.
2. use: 4-[(methyl) impurity]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino phenyl]benzamide as imatinib, mainly in the drug development and manufacturing process needs to be detected and controlled. It can affect the purity of imatinib and the quality of the drug.
3. preparation method: 4-[(3-pyridyne) methyl]-N-[4-methyl-3-[[4-(3-pyridyne) pyrimidin-2-yl]amino]phenyl]benzamide is usually formed during the synthesis or storage of imatine. Simultaneously with the preparation of imatinib, the synthesis reaction and storage conditions need to be optimized to reduce the formation of 4-[(meth) methyl]-N-[4-methyll -3-[[4-(3-pyridyl)pyrimidin-2-yl]amino] benzamide.
4. safety information: since 4-[(methyl) methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide is a degradation product or by-product of imatinib, most studies have focused on imatinib. According to the known information, the short-term and long-term side effects of imatinib in clinical use have been evaluated and monitored. Specific safety information on 4-[() methyl]-N-[4-methyll-3-[[4-(3-pyridl) pyrimidin-2-yl]amino]phenyl]benzamide may require further research. When using imatinib, it should be used correctly according to the guidance of doctors or pharmacists, in accordance with the dosage and usage in the drug instructions, and pay attention to possible adverse reactions and precautions.
1. nature: 4-[(1) methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino phenyl]benzamide is an organic compound with a chemical formula of C27H30N8O2. It is a by-product or degradation product of imatinib, usually in the form of its hydrochloride salt.
2. use: 4-[(methyl) impurity]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino phenyl]benzamide as imatinib, mainly in the drug development and manufacturing process needs to be detected and controlled. It can affect the purity of imatinib and the quality of the drug.
3. preparation method: 4-[(3-pyridyne) methyl]-N-[4-methyl-3-[[4-(3-pyridyne) pyrimidin-2-yl]amino]phenyl]benzamide is usually formed during the synthesis or storage of imatine. Simultaneously with the preparation of imatinib, the synthesis reaction and storage conditions need to be optimized to reduce the formation of 4-[(meth) methyl]-N-[4-methyll -3-[[4-(3-pyridyl)pyrimidin-2-yl]amino] benzamide.
4. safety information: since 4-[(methyl) methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide is a degradation product or by-product of imatinib, most studies have focused on imatinib. According to the known information, the short-term and long-term side effects of imatinib in clinical use have been evaluated and monitored. Specific safety information on 4-[() methyl]-N-[4-methyll-3-[[4-(3-pyridl) pyrimidin-2-yl]amino]phenyl]benzamide may require further research. When using imatinib, it should be used correctly according to the guidance of doctors or pharmacists, in accordance with the dosage and usage in the drug instructions, and pay attention to possible adverse reactions and precautions.
Last Update：2024-04-09 21:11:58
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View History
iMatinib related substance D
ethyl 4-[2-(ethoxycarbonylamino)ethyl]piperazine-1-carboxylate
(2S,3S)-2-CHLORO-3-METHYLVALERIC ACID
Tegoprazan intermediate
Magnesium bis(2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylate)
六甲基二硅硫烷
ethyl 6-ethoxy-4-[2-oxo-2-(2-thienyl)ethoxy]-3-quinolinecarboxylate
1-CYCLOHEXENYLACETIC ACID
TERT-BUTYL 3-(HYDROXYMETHYL)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
4-[2-(trifluoromethoxy)ethylsulfamoyl]benzoic acid
ethyl 4-[2-(ethoxycarbonylamino)ethyl]piperazine-1-carboxylate
(2S,3S)-2-CHLORO-3-METHYLVALERIC ACID
Tegoprazan intermediate
Magnesium bis(2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylate)
六甲基二硅硫烷
ethyl 6-ethoxy-4-[2-oxo-2-(2-thienyl)ethoxy]-3-quinolinecarboxylate
1-CYCLOHEXENYLACETIC ACID
TERT-BUTYL 3-(HYDROXYMETHYL)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
4-[2-(trifluoromethoxy)ethylsulfamoyl]benzoic acid